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ILC In Lung Wiki

Last updated: 2026-05-07

Welcome

I am Jheng-Syuan Shao, a researcher studying innate lymphoid cells (ILCs), with a particular focus on how ILCs shape pulmonary disease. I created this LLM-assisted wiki to help myself and readers who are curious about the ILC field quickly grasp the major conceptual threads, important mechanisms, and key papers that organize current thinking. The wiki is built from research articles that I find important, useful, or especially interesting, and it is structured as a source-aware knowledge map rather than a complete textbook or systematic review. This is a living document that will evolve as new literature and interpretation are added over time.

This homepage is designed as a starting point for browsing. Start with the overview, field history, and core evidence synthesis, then move into cell-specific entity pages, disease topics, regulatory mechanism maps, and source notes when you need traceability.

Start Here

Goal Best entry point
Understand the whole wiki ILC In Lung
Learn the field history ILC Research Trend From Then To Now
See the strongest integrated evidence Lung ILC Core Evidence Synthesis
Focus on ILC2 ILC2
Focus on ILC3 ILC3
Understand ILC-adaptive immunity crosstalk ILC Regulation Of Adaptive Immunity
Browse the reference library Reference Library

Core Knowledge Map

flowchart TB
    accTitle: Core Knowledge Map
    accDescr: Homepage map showing how readers should move from field orientation into core synthesis, entity hubs, topic pages, and source traceability.

    home["Start<br/>ILC in lung overview"] --> trend["Field history"]
    home --> core["Core evidence synthesis"]
    core --> ilc2["ILC2 hub"]
    core --> ilc3["ILC3 hub"]
    ilc2 --> ilc2_disease["Disease roles"]
    ilc2 --> ilc2_reg["Regulation map"]
    ilc3 --> ilc3_disease["Disease roles"]
    ilc3 --> ilc3_reg["Regulation map"]
    ilc2_disease --> sources["Source notes"]
    ilc2_reg --> sources
    ilc3_disease --> sources
    ilc3_reg --> sources

    classDef entry fill:#e8f3ff,stroke:#3b6ea8,stroke-width:2px,color:#17324d
    classDef synthesis fill:#eef7ed,stroke:#4d8a50,stroke-width:2px,color:#173d1d
    classDef cell fill:#fff4de,stroke:#b47a1f,stroke-width:2px,color:#4a3108
    classDef topic fill:#f6eefc,stroke:#7a55a3,stroke-width:2px,color:#2d1645
    classDef source fill:#f4f4f4,stroke:#777,stroke-width:1px,color:#222

    class home entry
    class trend,core synthesis
    class ilc2,ilc3 cell
    class ilc2_disease,ilc2_reg,ilc3_disease,ilc3_reg topic
    class sources source

Cell Entity Hubs

  • ILC2: canonical ILC2 hub with the integrated former working model, covering allergic amplification, viral AHR versus repair, macrophage niche effects, neuroimmune and metabolic regulation, stromal niches, interferon brakes, and IL-17-producing boundary states.
  • ILC3: canonical ILC3 hub with the integrated former working model, covering human lung baseline, IL-22 defense, neonatal pulmonary niches, ARDS and neutrophilic or steroid-resistant asthma, SCF/KIT stromal licensing, and IL-17-producing ILC classification cautions.

Disease And Mechanism Topics

  • ILC2 Roles In Pulmonary Disease: allergic asthma, respiratory viral AHR and repair, plastic/non-type-2 states, obesity-associated disease, silicosis-associated plasticity, and tumor/NK checkpoint context.
  • ILC3 Roles In Pulmonary Disease: bacterial defense, neonatal lung development, ARDS/lung injury, neutrophilic and steroid-resistant asthma, smoke-associated asthma, and noncanonical mediator branches.
  • ILC2 Functional Regulation Mechanisms: alarmins, lipid mediators, costimulation/checkpoints, metabolism, neuroimmune signaling, stromal/mechanical feedback, and infection-conditioned reprogramming.
  • ILC3 Functional Regulation Mechanisms: cytokine activation, stromal niches, transcriptional identity, taxonomy, AHR/STING/vitamin D/nutrition/stress axes, and glucocorticoid resistance.
  • ILC Regulation Of Adaptive Immunity: ILC2 OX40L control of local Th2/Treg expansion and gut/tonsil-labeled ILC3 regulation of CD4 T cells, Tregs, and regulatory B cells.

Synthesis And Companion Pages

The sections below preserve reference structure and project notes. Most readers can treat them as optional appendices.

Source Layer
  • Source Guide: explains how source notes are organized and how to read evidence strength.
  • Reference Library: browsable list of source notes for the local reference library.
  • Project Hub: project scope, priority questions, key pages, open risks, and next actions.
Project Notes
Rules And Notes
  • Wiki Rules: local rules for reading evidence confidence, page types, and source traceability.

This wiki is a research synthesis aid, not a clinical guideline. Claim-level confidence refers to biological claims and evidence directness, not to whether a PDF was successfully processed. Mouse perturbation, human lung tissue, sputum, blood, nasal airway, scRNA-seq, and review-level evidence are intentionally kept separate when they imply different levels of confidence.