Adaptive Immunity Source Review Notes

Scope

This audit records a private-wiki source-review pass completed on 2026-04-30.

The pass screened the local ILC source library for evidence that ILCs regulate adaptive immunity, with emphasis on T cells, B cells, and Tregs. Six previously provisional sources were promoted to source-reviewed evidence notes. Already focused OX40L and CTLA-4 sources were reused as supporting anchors rather than duplicated.

Sources Promoted

• 2013_innate_lymphoid_cells_regulate_cd4_t_cell_responses_to_intestinal_commensal_bacteria
• 2015_group_3_innate_lymphoid_cells_mediate_intestinal_selection_of_commensal_bacteria_specific_cd4_t_cells
• 2018_human_cd40_ligand_expressing_type_3_innate_lymphoid_cells_induce_il_10_producing_immature_transitional_regulator
• 2019_innate_lymphoid_cells_support_regulatory_t_cells_in_the_intestine_through_interleukin
• 2022_ilc3s_select_microbiota_specific_regulatory_t_cells_to_establish_tolerance_in_the_gut
• 2020_the_interplay_between_innate_lymphoid_cells_and_t_cells

Selection Logic

• Included: sources with direct ILC-to-T-cell, ILC-to-Treg, or ILC-to-B-cell mechanisms.
• Included: review-level ILC-T-cell synthesis for orientation only.
• Not upgraded here: sources where T cells or B cells were background disease context without a direct ILC-adaptive-immunity mechanism.

Knowledge-Layer Changes

• Added ILC Regulation Of Adaptive Immunity as a topic page.
• Updated the ILC2 and ILC3 entity hubs to point readers toward adaptive-immunity crosstalk.
• Updated ILC2 and ILC3 mechanism pages with OX40L, MHCII, IL-2, alphaV integrin, CD40L, BAFF, IL-15, and CTLA-4-linked adaptive-immunity branches.
• Updated the core evidence synthesis with a tissue-boundary-aware adaptive-immunity layer.

Interpretation Limits

• Lung-direct evidence is currently strongest for mouse ILC2 OX40L regulation of local Th2/Treg expansion.
• ILC3 adaptive-immunity evidence is strong mechanistically but mostly gut, tonsil, or blood context in the current library.
• Review-level ILC-T-cell framing should not substitute for primary source citations.