Focused Manual Ingest Batch 6
Scope
This audit records a private-wiki source-review pass completed on 2026-04-30.
The pass deep-ingested 10 previously provisional source notes. The purpose was to strengthen ILC2 regulatory architecture around trafficking, costimulation, immune egress, allergen memory, and human AIT monitoring, while adding gut/mucosal-labeled ILC3 mechanism context for IL-17D/CD93, reciprocal TF networks, NPM1/OXPHOS, and PDGF-D species divergence.
Sources Promoted
- 2018_s1p_dependent_interorgan_trafficking_of_group_2_innate_lymphoid_cells_supports_host_d
- 2018_tissue_restricted_adaptive_type_2_immunity_is_orchestrated_by_expression_of_the_costimulatory_molecule_ox40l_on
- 2021_trained_immunity_and_tolerance_in_innate_lymphoid_cells_monocytes_and_dendritic_cells_during_allergen_specific_i
- 2024_ilc2_derived_lif_licences_progress_from_tissue_to_systemic_immunity
- 2021_the_molecular_and_epigenetic_mechanisms_of_innate_lymphoid_cell_ilc_memory_and_its_re
- 2021_interleukin_17d_regulates_group_3_innate_lymphoid_cell_function_through_its_receptor
- 2021_reciprocal_transcription_factor_networks_govern_tissue_resident_ilc3_subset_function
- 2024_nucleophosmin_1_promotes_mucosal_immunity_by_supporting_mitochondrial_oxidative_phosphorylation_and_ilc3_activit
- 2026_divergent_ilc3_responses_to_pdgf_d_control_mucosal_immunity
- 2019_innate_lymphoid_cells_of_the_lung
Knowledge-Layer Changes
- Added S1P-dependent inflammatory ILC2 trafficking, ILC2 OX40L costimulation, ILC2-derived LIF immune-egress control, and epigenetic ILC2 memory to the ILC2 hub and topic pages.
- Added human blood AIT immune-monitoring context while preserving the blood compartment boundary.
- Added gut/mucosal-labeled ILC3 regulation branches: IL-17D/CD93, reciprocal TF-network identity, NPM1-p65-TFAM mitochondrial OXPHOS, and PDGF-D receptor/species divergence.
- Added one lung ILC review as an orientation source rather than primary mechanistic evidence.
Interpretation Limits
- Gut and mucosal ILC3 mechanisms remain extrapulmonary context unless direct lung data are cited.
- Human AIT evidence is blood immune-monitoring evidence, not lung tissue causality.
- Mouse ILC2 trafficking, OX40L, LIF, and memory findings should preserve model, stimulus, and compartment labels.