Adaptive Immunity Source Review Notes 2
Scope
This audit records a private-wiki source-review pass completed on 2026-04-30.
The pass promoted 10 additional sources relevant to ILC regulation of adaptive immunity, indirect tolerance pathways, review-level ILC-adaptive framing, and taxonomy boundaries.
Sources Promoted
- 2014_microbiota_dependent_crosstalk_between_macrophages_and_ilc3_promotes_intestinal_homeo
- 2014_innate_lymphoid_cells_and_asthma
- 2015_the_biology_of_innate_lymphoid_cells
- 2016_innate_lymphoid_cells_as_regulators_of_immunity_inflammation_and_tissue_homeostasis
- 2018_orchestration_of_intestinal_homeostasis_and_tolerance_by_group_3_innate_lymphoid_cell
- 2020_ilc2s_are_the_predominant_source_of_intestinal_ilc_derived_il_10
- 2021_antigen_presenting_innate_lymphoid_cells_orchestrate_neuroinflammation
- 2021_dysregulation_of_ilc3s_unleashes_progression_and_immunotherapy_resistance_in_colon_cancer
- 2025_ilc3s_sense_gut_microbiota_through_sting_to_initiate_immune_tolerance
- 2026_rorgammat_dendritic_cells_are_a_distinct_lymphoid_derived_lineage
Selection Logic
- Included direct ILC3-T-cell antigen-presentation sources outside the gut tolerance setting.
- Included gut ILC3 and ILC2 tolerance sources that expand regulatory mechanisms beyond the first adaptive-immunity pass.
- Included review sources only when they improve reader orientation without replacing primary evidence.
- Included RORgammat-positive DC lineage work as an attribution boundary for ILC3-adjacent Treg biology.
Knowledge-Layer Changes
- Expanded ILC Regulation Of Adaptive Immunity with context-dependent antigen presentation, indirect tolerance, ILC2 IL-10, and taxonomy-boundary sections.
- Updated ILC2/ILC3 entity hubs and functional regulation topics.
- Updated the core evidence synthesis representative source spine and adaptive-immunity claims.
Interpretation Limits
- Most new mechanisms remain gut, CNS, colon-cancer, or lineage-taxonomy context rather than direct pulmonary evidence.
- Lung-direct ILC-adaptive evidence still centers on mouse ILC2 OX40L unless new pulmonary ILC3-T/B/Treg studies are added.