RORgammat + dendritic cells are a distinct lymphoid-derived lineage

Citation

Verified title: RORgammat + dendritic cells are a distinct lymphoid-derived lineage
Publication year: 2026
DOI: 10.1126/sciimmunol.aed7439
Metadata source: crossref-title (confidence: high)
Original local title: RORgammat+ dendritic cells are a distinct lymphoid-derived lineage

Ingest Mode

Mode: focused manual crystallization mode
Meaning: this source page has been manually reviewed for the adaptive-immunity follow-up question, including model system, tissue compartment, immune-cell target, assay directness, and claim-level boundaries.
Required boundary: reusable claims should preserve species, tissue, disease model, and whether evidence is primary perturbation, human association, ex vivo function, lineage taxonomy, or review-level synthesis.

Source Type

primary mouse RORgammat-positive dendritic-cell lineage study - Evidence profile: lineage tracing, single-cell transcriptomics, RORgammat-positive DC progenitors, lymphoid-derived RORgammat-positive DC lineage, and peripheral Treg-mediated immune homeostasis. - Knowledge note status: source-reviewed boundary note for separating ILC3 from RORgammat-positive DC adaptive-tolerance mechanisms.

Evidence Profile

Overall confidence: high for source-specific mouse evidence that RORgammat-positive DCs are a distinct lymphoid-derived lineage important for peripheral Treg homeostasis. - Evidence tags: #source/primary #species/mouse #tissue/gut #cell/dendritic_cell #cell/Treg #cell/ILC3 #assay/scRNAseq #assay/RNAseq #assay/flow #outcome/homeostasis #axis/adaptive_immunity #axis/taxonomy #status/focused_crystallization - Primary biological axis: RORgammat-positive DCs are lineage-distinct from ILC3s and contribute to peripheral Treg-mediated homeostasis.

Why It Matters Here

This source is a classification guardrail: not every RORgammat-positive lymphoid-derived antigen-presenting tolerance signal should be assigned to ILC3s.

Key Findings

Lineage tracing and single-cell transcriptomics identified bone-marrow Rorc(t)+ progenitors linked to ILC3 and RORgammat-positive DC lineages.
The source defines murine RORgammat-positive DCs as a distinct lymphoid-derived lineage.
This lineage is described as important for peripheral Treg-mediated immune homeostasis.
For this wiki, the value is taxonomy and attribution caution, not lung ILC3 mechanism evidence.

Claim-Level Confidence

High confidence: RORgammat-positive DCs are a distinct lineage in the reported mouse system.
Medium-high confidence: this source should sharpen attribution boundaries for Treg tolerance mechanisms near ILC3 biology.
Low confidence: it is not direct lung ILC3 evidence.

Methods and Context

Species/context: mouse lineage tracing and single-cell transcriptomics.
Compartment: immune developmental and peripheral homeostasis context.
Assay directness: strong for lineage boundary; indirect for lung.
Best wiki use: taxonomy guardrail for ILC3-adjacent tolerance mechanisms.

Caveats

Do not relabel RORgammat-positive DC functions as ILC3 functions.
Keep as a boundary source.
Avoid pulmonary extrapolation.

Contradiction and Supersession

Contradiction status: may refine interpretation of RORgammat-positive antigen-presenting cells near ILC3 biology.
Supersession status: recent taxonomy update; does not supersede ILC3 MHCII papers but adds caution.