Innate lymphoid cells and asthma

Citation

Verified title: Innate lymphoid cells and asthma
Publication year: 2014
DOI: 10.1016/j.jaci.2014.02.015
Metadata source: crossref-doi (confidence: high)
Original local title: Innate lymphoid cells and asthma

Ingest Mode

Mode: focused manual crystallization mode
Meaning: this source page has been manually reviewed for the adaptive-immunity follow-up question, including model system, tissue compartment, immune-cell target, assay directness, and claim-level boundaries.
Required boundary: reusable claims should preserve species, tissue, disease model, and whether evidence is primary perturbation, human association, ex vivo function, lineage taxonomy, or review-level synthesis.

Source Type

review on ILCs and asthma - Evidence profile: asthma framing across adaptive Th2 immunity and innate lymphoid pathways, especially nonallergic or innate asthma contexts. - Knowledge note status: source-reviewed review note for lung/asthma orientation, not primary mechanism evidence.

Evidence Profile

Overall confidence: medium for review-level asthma framing. - Evidence tags: #source/review #species/human #species/mouse #tissue/lung #cell/ILC2 #cell/T_cell #disease/asthma #outcome/airway_hyperresponsiveness #axis/adaptive_immunity #axis/ILC_airway_inflammation #status/focused_crystallization - Primary biological axis: asthma can include adaptive Th2 and innate ILC2-linked type 2 pathways that should be separated by evidence type.

Why It Matters Here

This review helps position ILC2 biology against classical adaptive Th2 asthma, making it useful for reader orientation but not as a primary mechanistic anchor.

Key Findings

The review contrasts allergen-specific adaptive Th2 asthma with innate pathways involving ILCs.
It frames nonallergic asthma triggers such as pollution, infection, or obesity as contexts where innate immunity can be central.
The source is useful for conceptual contrast between adaptive and innate type 2 pathways.
Specific ILC2 mechanistic claims should still cite primary lung/allergen/infection studies.

Claim-Level Confidence

Medium confidence: useful for review-level asthma framing.
Low confidence: not sufficient alone for source-specific mechanism claims.

Methods and Context

Source type: review.
Compartment: lung/asthma literature.
Assay directness: not primary experimental evidence.
Best wiki use: introduction and contrast between adaptive Th2 and ILC2 asthma logic.

Caveats

Do not use as sole support for a mechanistic perturbation claim.
Preserve review-level status.
Keep Th2 and ILC2 claims distinct.

Contradiction and Supersession

Contradiction status: explains why asthma can be framed through both adaptive and innate type 2 pathways.
Supersession status: older review; use for historical framing.