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ILC3s promote intestinal tuft cell hyperplasia and anthelmintic immunity through RANK signaling

Citation

  • Verified title: ILC3s promote intestinal tuft cell hyperplasia and anthelmintic immunity through RANK signaling
  • Publication year: 2025
  • DOI: 10.1126/sciimmunol.adn1491
  • Metadata source: crossref-title (confidence: high)
  • Original local title: ILC3s promote intestinal tuft cell hyperplasia and anthelmintic immunity through RANK signaling

Ingest Mode

  • Mode: focused manual crystallization mode
  • Meaning: this source page has been manually reviewed for final provisional-source cleanup, including source type, tissue context, model boundaries, and whether the source should enter durable synthesis.
  • Required boundary: reusable claims should preserve species, tissue, mediator, disease model, and whether evidence is primary or review-level synthesis.

Source Type

  • primary gut ILC3-tuft-cell/RANK study
  • Evidence profile: ILC3s promote intestinal tuft-cell hyperplasia and anthelmintic immunity through RANK signaling.
  • Knowledge note status: source-reviewed evidence note; use according to the boundary notes below.

Evidence Profile

  • Overall confidence: source-specific biological confidence, not processing confidence.
  • Evidence tags: #source/primary #species/mouse #tissue/gut #cell/ILC3 #cell/epithelial_cell #outcome/infection #axis/RANK #axis/ILC_regulation #status/focused_crystallization
  • Primary biological axis: ILC3s promote intestinal tuft-cell hyperplasia and anthelmintic immunity through RANK signaling.

Why It Matters Here

This source adds ILC3 RANK signaling promotes tuft-cell hyperplasia and anthelmintic immunity to the reference library as ILC3 gut epithelial crosstalk context. It should be used only where that role fits the reader-facing biology narrative.

Key Findings

  • Adds a gut ILC3-RANK-tuft-cell branch linked to anthelmintic immunity.
  • Complements but should not be collapsed with RANKL/RANK restraint of ILC3 effector cytokines.
  • Useful for gut epithelial crosstalk context, not direct lung evidence.

Claim-Level Confidence

  • Medium-high confidence: source-specific intestinal ILC3-RANK-tuft-cell branch.
  • Low confidence: direct pulmonary relevance is not established.

Methods and Context

  • Source-specific context: primary gut ILC3-tuft-cell/RANK study.
  • Best wiki use: ILC3 gut epithelial crosstalk context.
  • Evidence directness: strongest for the source's own tissue/model; indirect for lung unless lung evidence is present.

Caveats

  • Distinguish this RANK branch from RANKL-mediated ILC3 restraint.
  • Preserve species, tissue compartment, and source-type labels.
  • Do not use review-level sources as sole support for mechanism-specific causal claims.

Contradiction and Supersession

  • Contradiction status: no direct contradiction resolved in this cleanup pass; use as context alongside primary source anchors.
  • Supersession status: not superseded, but some older reviews are best treated as historical or orientation sources.

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