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ZBTB46 defines and regulates ILC3s that protect the intestine

Citation

  • Verified title: ZBTB46 defines and regulates ILC3s that protect the intestine
  • Publication year: 2022
  • DOI: 10.1038/s41586-022-04934-4
  • Metadata source: crossref-doi (confidence: high)
  • Original local title: ZBTB46 defines and regulates ILC3s that protect the intestine

Ingest Mode

  • Mode: focused manual crystallization mode
  • Meaning: this source page has been manually reviewed for final provisional-source cleanup, including source type, tissue context, model boundaries, and whether the source should enter durable synthesis.
  • Required boundary: reusable claims should preserve species, tissue, mediator, disease model, and whether evidence is primary or review-level synthesis.

Source Type

  • primary gut ILC3 identity/protection study
  • Evidence profile: ZBTB46 defines and regulates an intestinal ILC3 branch linked to tissue protection.
  • Knowledge note status: source-reviewed evidence note; use according to the boundary notes below.

Evidence Profile

  • Overall confidence: source-specific biological confidence, not processing confidence.
  • Evidence tags: #source/primary #species/mouse #tissue/gut #cell/ILC3 #assay/flow #assay/RNAseq #outcome/homeostasis #outcome/protection #axis/ILC3_identity #axis/ILC_regulation #status/focused_crystallization
  • Primary biological axis: ZBTB46 defines and regulates an intestinal ILC3 branch linked to tissue protection.

Why It Matters Here

This source adds ZBTB46 defines and regulates protective intestinal ILC3s to the reference library as ILC3 regulation and identity context. It should be used only where that role fits the reader-facing biology narrative.

Key Findings

  • Adds ZBTB46 as a gut ILC3 identity/regulatory marker or program.
  • Supports tissue-protective intestinal ILC3 context.
  • Useful for ILC3 identity architecture, not direct lung evidence.

Claim-Level Confidence

  • High confidence: source-specific intestinal ZBTB46-ILC3 relationship in the reported system.
  • Medium confidence: useful ILC3 identity context.
  • Low confidence: direct pulmonary ZBTB46-ILC3 claims need lung evidence.

Methods and Context

  • Source-specific context: primary gut ILC3 identity/protection study.
  • Best wiki use: ILC3 regulation and identity context.
  • Evidence directness: strongest for the source's own tissue/model; indirect for lung unless lung evidence is present.

Caveats

  • Keep intestinal tissue-protection context explicit.
  • Preserve species, tissue compartment, and source-type labels.
  • Do not use review-level sources as sole support for mechanism-specific causal claims.

Contradiction and Supersession

  • Contradiction status: no direct contradiction resolved in this cleanup pass; use as context alongside primary source anchors.
  • Supersession status: not superseded, but some older reviews are best treated as historical or orientation sources.

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