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The interplay between innate lymphoid cells and T cells

Citation

  • Verified title: The interplay between innate lymphoid cells and T cells
  • Publication year: 2020
  • DOI: 10.1038/s41385-020-0320-8
  • Metadata source: crossref-doi (confidence: high)
  • Original local title: The interplay between innate lymphoid cells and T cells

Ingest Mode

  • Mode: focused manual crystallization mode
  • Meaning: this source page has been manually reviewed for the adaptive-immunity question, including model system, tissue compartment, relevant figures/text, assay directness, and claim-level boundaries.
  • Required boundary: reusable claims should preserve species, tissue, immune-cell target, and whether evidence is primary perturbation, human association, ex vivo function, or review-level synthesis.

Source Type

  • review on ILC-T-cell interactions
  • Evidence profile: review-level synthesis of ILC effects on T-cell activation, differentiation, tolerance, tissue immunity, and bidirectional regulation across mucosal contexts.
  • Knowledge note status: source-reviewed review note suitable for conceptual framing only; primary mechanistic claims should cite primary sources.

Evidence Profile

  • Overall confidence: medium for conceptual framing of ILC-T-cell crosstalk; primary-source confidence depends on the underlying cited studies.
  • Evidence tags: #source/review #species/human #species/mouse #cell/ILC2 #cell/ILC3 #cell/T_cell #cell/Treg #tissue/mucosa #outcome/homeostasis #outcome/inflammation #axis/adaptive_immunity #axis/ILC_regulation #status/focused_crystallization
  • Primary biological axis: ILCs and T cells regulate each other through context-dependent cytokine, costimulatory, antigen-presentation, and tissue-niche pathways.

Why It Matters Here

This review is useful as a map of the field and vocabulary for ILC-T-cell interactions, but it should not replace primary papers for durable biological claims.

Key Findings

  • The review emphasizes that ILC effects on T cells depend on tissue, inflammatory context, subset, and timing.
  • It frames ILC-T-cell interactions as bidirectional rather than purely ILC-to-T-cell regulation.
  • It covers both effector T-cell reinforcement and tolerance-associated pathways, including regulatory T-cell contexts.
  • For this wiki, it provides reader orientation but should be paired with primary source links for specific mechanisms.

Claim-Level Confidence

  • Medium confidence: review-level statements can support field framing and reading routes.
  • High confidence for this page's use: the source is relevant to ILC-T-cell crosstalk as a conceptual topic.
  • Low confidence: review statements alone should not be used to upgrade pulmonary mechanism claims.

Methods and Context

  • Source type: review article.
  • Compartment: broad mucosal and immune-system framing rather than one tissue-specific perturbation model.
  • Assay directness: not primary experimental evidence.
  • Best wiki use: orientation paragraph, vocabulary, and cross-source synthesis support.

Caveats

  • Use as conceptual framing, not as the main citation for a mechanistic claim.
  • Separate ILC2-Th2 costimulation, ILC3-MHCII tolerance, and ILC3-Treg mechanisms when citing primary sources.
  • Review-level generality should not erase tissue labels.

Contradiction and Supersession

  • Contradiction status: highlights that ILC-T-cell crosstalk can amplify or restrain immunity depending on context.
  • Supersession status: not superseded; remains useful for orientation.

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