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Innate Lymphoid Cells: Diversity, Plasticity, and Unique Functions in Immunity

Citation

  • Verified title: Innate Lymphoid Cells: Diversity, Plasticity, and Unique Functions in Immunity
  • Publication year: 2018
  • DOI: 10.1016/j.immuni.2018.05.013
  • Metadata source: crossref-doi (confidence: high)
  • Original local title: Innate Lymphoid Cells Diversity, Plasticity, and Unique Functions in Immunity

Ingest Mode

  • Mode: focused manual crystallization mode
  • Meaning: this source page has been manually reviewed for final provisional-source cleanup, including source type, tissue context, model boundaries, and whether the source should enter durable synthesis.
  • Required boundary: reusable claims should preserve species, tissue, mediator, disease model, and whether evidence is primary or review-level synthesis.

Source Type

  • review on ILC diversity and plasticity
  • Evidence profile: review-level synthesis of ILC subset diversity, plasticity, and non-redundant immune functions.
  • Knowledge note status: source-reviewed evidence note; use according to the boundary notes below.

Evidence Profile

  • Overall confidence: source-specific biological confidence, not processing confidence.
  • Evidence tags: #source/review #species/human #species/mouse #cell/ILC1 #cell/ILC2 #cell/ILC3 #axis/ILC_plasticity #axis/ILC_taxonomy #status/focused_crystallization
  • Primary biological axis: review-level synthesis of ILC subset diversity, plasticity, and non-redundant immune functions.

Why It Matters Here

This source adds ILC diversity, plasticity, and unique functions to the reference library as trend digest, ILC2/ILC3 taxonomy guardrails. It should be used only where that role fits the reader-facing biology narrative.

Key Findings

  • Useful for explaining why ILC subset labels must be interpreted as states and functions, not only static names.
  • Supports boundary-state and plasticity framing.
  • Should be paired with primary lung, nasal, sputum, or gut sources for specific claims.

Claim-Level Confidence

  • Medium-high confidence: useful review-level plasticity and diversity framing.
  • Low confidence: not a stand-alone disease-mechanism source.

Methods and Context

  • Source-specific context: review on ILC diversity and plasticity.
  • Best wiki use: trend digest, ILC2/ILC3 taxonomy guardrails.
  • Evidence directness: strongest for the source's own tissue/model; indirect for lung unless lung evidence is present.

Caveats

  • Do not use broad plasticity framing to erase tissue or marker boundaries.
  • Preserve species, tissue compartment, and source-type labels.
  • Do not use review-level sources as sole support for mechanism-specific causal claims.

Contradiction and Supersession

  • Contradiction status: no direct contradiction resolved in this cleanup pass; use as context alongside primary source anchors.
  • Supersession status: not superseded, but some older reviews are best treated as historical or orientation sources.

Pages Updated From This Source