Skip to content

Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation

Citation

  • Verified title: Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation
  • Publication year: 2017
  • DOI: 10.1016/j.cell.2017.07.027
  • Metadata source: crossref-doi (confidence: high)
  • Original local title: Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation

Ingest Mode

  • Mode: focused manual crystallization mode
  • Meaning: this source page has been manually reviewed for final provisional-source cleanup, including source type, tissue context, model boundaries, and whether the source should enter durable synthesis.
  • Required boundary: reusable claims should preserve species, tissue, mediator, disease model, and whether evidence is primary or review-level synthesis.

Source Type

  • primary/research source on regulatory ILC-like intestinal inflammation control
  • Evidence profile: regulatory ILC-like cells can restrain innate intestinal inflammation in the reported gut context.
  • Knowledge note status: source-reviewed evidence note; use according to the boundary notes below.

Evidence Profile

  • Overall confidence: source-specific biological confidence, not processing confidence.
  • Evidence tags: #source/primary #species/mouse #tissue/gut #cell/ILC #outcome/inflammation #axis/ILC_regulation #status/focused_crystallization
  • Primary biological axis: regulatory ILC-like cells can restrain innate intestinal inflammation in the reported gut context.

Why It Matters Here

This source adds Regulatory ILCs control innate intestinal inflammation to the reference library as adaptive/regulatory context with gut label. It should be used only where that role fits the reader-facing biology narrative.

Key Findings

  • Adds an intestinal regulatory-ILC-like restraint branch.
  • Relevant to the broader concept that ILCs can restrain as well as promote inflammation.
  • Current use should remain gut/intestinal and not be converted into a lung ILC2 or ILC3 claim.

Claim-Level Confidence

  • Medium-high confidence: source-specific intestinal regulatory ILC-like restraint in the reported system.
  • Low confidence: direct lung relevance is not established here.

Methods and Context

  • Source-specific context: primary/research source on regulatory ILC-like intestinal inflammation control.
  • Best wiki use: adaptive/regulatory context with gut label.
  • Evidence directness: strongest for the source's own tissue/model; indirect for lung unless lung evidence is present.

Caveats

  • Do not merge regulatory ILC-like cells with canonical lung ILC2 or ILC3 without marker and tissue evidence.
  • Preserve species, tissue compartment, and source-type labels.
  • Do not use review-level sources as sole support for mechanism-specific causal claims.

Contradiction and Supersession

  • Contradiction status: no direct contradiction resolved in this cleanup pass; use as context alongside primary source anchors.
  • Supersession status: not superseded, but some older reviews are best treated as historical or orientation sources.

Pages Updated From This Source