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Innate lymphoid cells: major players in inflammatory diseases

Citation

  • Verified title: Innate lymphoid cells: major players in inflammatory diseases
  • Publication year: 2017
  • DOI: 10.1038/nri.2017.86
  • Metadata source: crossref-doi (confidence: high)
  • Original local title: Innate lymphoid cells major players in inflammatory diseases

Ingest Mode

  • Mode: focused manual crystallization mode
  • Meaning: this source page has been manually reviewed for final provisional-source cleanup, including source type, tissue context, model boundaries, and whether the source should enter durable synthesis.
  • Required boundary: reusable claims should preserve species, tissue, mediator, disease model, and whether evidence is primary or review-level synthesis.

Source Type

  • review on ILCs in inflammatory disease
  • Evidence profile: review-level disease framing across ILC subsets and inflammatory contexts.
  • Knowledge note status: source-reviewed evidence note; use according to the boundary notes below.

Evidence Profile

  • Overall confidence: source-specific biological confidence, not processing confidence.
  • Evidence tags: #source/review #species/human #species/mouse #cell/ILC1 #cell/ILC2 #cell/ILC3 #outcome/inflammation #axis/ILC_disease #status/focused_crystallization
  • Primary biological axis: review-level disease framing across ILC subsets and inflammatory contexts.

Why It Matters Here

This source adds ILCs as major players in inflammatory diseases to the reference library as trend digest and source spine. It should be used only where that role fits the reader-facing biology narrative.

Key Findings

  • Useful as broad inflammatory-disease orientation.
  • Supports disease-context thinking across ILC subsets.
  • Should not replace lung/asthma/ARDS primary source anchors.

Claim-Level Confidence

  • Medium confidence: useful review-level disease context.
  • Low confidence: not a primary source for any specific pulmonary mechanism.

Methods and Context

  • Source-specific context: review on ILCs in inflammatory disease.
  • Best wiki use: trend digest and source spine.
  • Evidence directness: strongest for the source's own tissue/model; indirect for lung unless lung evidence is present.

Caveats

  • Use as a routing review rather than a causal anchor.
  • Preserve species, tissue compartment, and source-type labels.
  • Do not use review-level sources as sole support for mechanism-specific causal claims.

Contradiction and Supersession

  • Contradiction status: no direct contradiction resolved in this cleanup pass; use as context alongside primary source anchors.
  • Supersession status: not superseded, but some older reviews are best treated as historical or orientation sources.

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