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The evolution of innate lymphoid cells

Citation

  • Verified title: The evolution of innate lymphoid cells
  • Publication year: 2016
  • DOI: 10.1038/ni.3459
  • Metadata source: crossref-doi (confidence: high)
  • Original local title: The evolution of innate lymphoid cells

Ingest Mode

  • Mode: focused manual crystallization mode
  • Meaning: this source page has been manually reviewed for final provisional-source cleanup, including source type, tissue context, model boundaries, and whether the source should enter durable synthesis.
  • Required boundary: reusable claims should preserve species, tissue, mediator, disease model, and whether evidence is primary or review-level synthesis.

Source Type

  • review on evolutionary framing of ILC biology
  • Evidence profile: field-level review placing ILCs within immune-system evolution and barrier immunity.
  • Knowledge note status: source-reviewed evidence note; use according to the boundary notes below.

Evidence Profile

  • Overall confidence: source-specific biological confidence, not processing confidence.
  • Evidence tags: #source/review #species/human #species/mouse #cell/ILC1 #cell/ILC2 #cell/ILC3 #cell/NK #axis/ILC_taxonomy #status/focused_crystallization
  • Primary biological axis: field-level review placing ILCs within immune-system evolution and barrier immunity.

Why It Matters Here

This source adds Evolution of ILCs to the reference library as trend digest and source spine. It should be used only where that role fits the reader-facing biology narrative.

Key Findings

  • Useful for broad historical and conceptual framing of ILC evolution.
  • Helps explain why ILCs are often discussed as innate counterparts to helper T-cell programs.
  • Does not provide a direct pulmonary disease mechanism.

Claim-Level Confidence

  • Medium confidence: useful review-level orientation for field history.
  • Low confidence: not a source for lung-specific mechanistic claims.

Methods and Context

  • Source-specific context: review on evolutionary framing of ILC biology.
  • Best wiki use: trend digest and source spine.
  • Evidence directness: strongest for the source's own tissue/model; indirect for lung unless lung evidence is present.

Caveats

  • Use for historical context only.
  • Preserve species, tissue compartment, and source-type labels.
  • Do not use review-level sources as sole support for mechanism-specific causal claims.

Contradiction and Supersession

  • Contradiction status: no direct contradiction resolved in this cleanup pass; use as context alongside primary source anchors.
  • Supersession status: not superseded, but some older reviews are best treated as historical or orientation sources.

Pages Updated From This Source