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Tissue-Specific Features of Innate Lymphoid Cells

Citation

  • Verified title: Tissue-Specific Features of Innate Lymphoid Cells
  • Publication year: 2020
  • DOI: 10.1016/j.it.2020.08.009
  • Metadata source: crossref-doi (confidence: high)
  • Original local title: Tissue-Specific Features of Innate Lymphoid Cells

Ingest Mode

  • Mode: focused manual crystallization mode
  • Meaning: this source page has been manually reviewed for the ILC2 regulatory-context question, including tissue compartment, model system, regulatory mediator, assay directness, and whether the source is primary or review-level evidence.
  • Required boundary: reusable claims should preserve species, tissue, mediator, disease model, and whether evidence is primary perturbation or review-level synthesis.

Source Type

  • review on tissue-specific ILC phenotypes and functions
  • Evidence profile: ILCs are tissue-resident or tissue-shaped cells with anatomical-location-specific phenotypes and functions across humans and mice.
  • Knowledge note status: source-reviewed evidence note suitable for ILC2 regulation context.

Evidence Profile

  • Overall confidence: source-specific confidence is assigned to the biological claim below, not to PDF processing.
  • Evidence tags: #source/review #species/human #species/mouse #tissue/lung #tissue/gut #tissue/skin #cell/ILC1 #cell/ILC2 #cell/ILC3 #cell/NK #outcome/homeostasis #outcome/infection #outcome/inflammation #axis/ILC_tissue_niche #status/focused_crystallization
  • Primary biological axis: ILCs are tissue-resident or tissue-shaped cells with anatomical-location-specific phenotypes and functions across humans and mice.

Why It Matters Here

This source adds tissue-specific ILC features to the ILC2 regulatory map. Its durable use depends on tissue and source-type boundaries: primary studies can support source-specific mechanisms, while reviews should orient interpretation and point to primary anchors.

Key Findings

  • The review emphasizes that ILCs are strongly shaped by tissue location.
  • It supports tissue-specific interpretation of ILC1, ILC2, ILC3, NK, and LTi-like compartments.
  • It is useful as a guardrail against moving gut, skin, blood, or lung claims across compartments without matching evidence.
  • Use it as review-level context for tissue labels and interpretation boundaries.

Claim-Level Confidence

  • Medium-high confidence: tissue specificity is a mature organizing principle in ILC biology.
  • Medium confidence: the review is useful for framing but should not replace source-specific primary evidence.

Methods and Context

  • Source-specific context: review-level synthesis of human and mouse tissue ILC literature.
  • Best wiki use: ILC2 functional regulation, tissue-context guardrails, and source routing.
  • Assay directness: strongest for the source tissue/model; indirect for lung disease unless lung data are present.

Caveats

  • Do not use this review alone to claim that a mechanism operates in lung.
  • Preserve species, tissue compartment, mediator, and disease-model labels.
  • Reviews should frame the field; primary sources should anchor causal claims.

Contradiction and Supersession

  • Contradiction status: complements the current ILC2 regulatory map by adding tissue-context, developmental, metabolic, neuroimmune, epithelial, or therapeutic framing.
  • Supersession status: not superseded; use alongside direct pulmonary ILC2 sources with explicit evidence labels.

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