Innate lymphoid cells in lung infection and immunity

Citation

Verified title: Innate lymphoid cells in lung infection and immunity
Publication year: 2018
DOI: 10.1111/imr.12712
Metadata source: crossref-doi (confidence: high)
Original local title: Innate lymphoid cells in lung infection and immunity

Ingest Mode

Mode: focused manual crystallization mode
Meaning: this source page was manually reviewed for source text, model context, assay directness, and claim boundaries.
Durable synthesis status: selected source-specific claims were propagated into entity/topic/digest pages only where evidence strength and context labels are preserved.

Source Type

review of ILCs in lung infection and immunity
Evidence profile: lung-invading pathogen map, ILC subset effector functions, and review-level synthesis across viral, bacterial, fungal, and helminth contexts.
Knowledge note status: source-reviewed review note suitable for lung infection routing and evidence-map context.

Evidence Profile

Overall confidence: medium for review-level pathogen-to-ILC mapping; lower for mechanistic strength unless traced to primary sources.
Evidence tags: #source/review #species/mixed #tissue/lung #cell/ILC1 #cell/ILC2 #cell/ILC3 #cell/NK #outcome/infection #outcome/repair #outcome/inflammation #axis/ILC_lung_infection #status/focused_crystallization
Primary biological axis: lung pathogens engage different ILC modules, including ILC2 repair/type 2 programs and ILC3 IL-17/IL-22 bacterial-defense programs.

Why It Matters Here

This review is a useful reference-map page for readers entering the lung infection branch. It links pathogen classes to ILC outputs but should remain a route into primary source notes rather than a high-confidence mechanistic anchor.

Key Findings

The review organizes lung ILC responses across respiratory viruses, bacterial pathogens such as Streptococcus pneumoniae and Mycobacterium tuberculosis, fungal infection, and helminth contexts.
It highlights ILC2-derived amphiregulin/IL-5/IL-13 and ILC3-derived IL-17/IL-22 as recurring lung infection or repair mediators.
It underscores that lung ILCs can contribute to both protection and immune pathology depending on pathogen and timing.
The page is best used as a disease-orientation map for source navigation.

Claim-Level Confidence

Medium confidence: lung infection is a major organizing context for ILC2 and ILC3 biology.
Low-to-medium confidence: specific mediator-pathogen claims should be checked against cited primary papers.
Low confidence: this review should not be used alone to make causal or therapeutic claims.

Methods and Context

Source type: narrative review.
Evidence directness: synthesis across primary studies.
Best wiki use: infection reading route, pathogen table interpretation, and lung ILC subset overview.

Caveats

Pathogen categories should not be collapsed; influenza, RSV, pneumococcus, Mtb, and fungi differ sharply.
Review tables may include unpublished or preliminary context; cite primary sources for durable claims.
Protective and pathogenic ILC roles must be time- and model-labeled.

Contradiction and Supersession

Contradiction status: explains why infection sources may show both repair and pathology.
Supersession status: not superseded; use as an orientation layer.