ILC3 Mucosal Regulation Source Review Notes
Scope
This audit records a private-wiki source-review pass completed on 2026-05-04.
The pass promoted 10 additional sources centered on gut/mucosal ILC3 regulatory circuitry. The goal was to strengthen ILC3 mechanism coverage while keeping these sources explicitly labeled as extrapulmonary context for the lung wiki.
Sources Promoted
- 2018_the_tumor_necrosis_factor_superfamily_member_rankl_suppresses_effector_cytokine_production_in_group_3_innate_lym
- 2019_a_circadian_clock_is_essential_for_homeostasis_of_group_3_innate_lymphoid_cells_in_th
- 2019_light_entrained_and_brain_tuned_circadian_circuits_regulate_ilc3s_and_gut_homeostasis
- 2019_metabolite_sensing_receptor_ffar2_regulates_colonic_group_3_innate_lymphoid_cells_and
- 2020_feeding_dependent_vip_neuron_ilc3_circuit_regulates_the_intestinal_barrier
- 2020_the_neuropeptide_vip_confers_anticipatory_mucosal_immunity_by_regulating_ilc3_activit
- 2021_vasoactive_intestinal_peptide_promotes_host_defense_against_enteric_pathogens_by_modu
- 2020_activation_and_suppression_of_group_3_innate_lymphoid_cells_in_the_gut
- 2022_trained_ilc3_responses_promote_intestinal_defense
- 2022_group_3_innate_lymphoid_cells_produce_the_growth_factor_hb_egf_to_protect_the_intestine_from_tnf_mediated_inflam
Knowledge-Layer Changes
- Expanded ILC3 functional regulation mechanisms with RANKL/RANK restraint, circadian timing, FFAR2 metabolite sensing, VIP neuroimmune circuits, trained ILC3 defense, and HB-EGF tissue protection.
- Updated ILC3, ILC3 roles in pulmonary disease, ILC Regulation Of Adaptive Immunity, and Lung ILC Core Evidence Synthesis.
Interpretation Limits
- These sources mainly support gut, intestinal barrier, enteric infection, or mucosal neuroimmune mechanisms.
- They should be used as mechanism comparators for lung ILC3 biology, not as direct pulmonary disease evidence.